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2025

Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure

Xue Wu, Qiran Chen, Wei-Chun Chou, Fiona P Maunsell, Lisa A Tell, Ronald E Baynes, Jennifer L Davis, Majid Jaberi-Douraki, Jim E Riviere, Zhoumeng Lin

Toxicological Sciences, Volume 203, Issue 2, February 2025, Pages 181–194

Effects of Serum Insulin and Insulin-Like Growth Factor 1 Levels on the Association between Fetal Growth and Per- and Polyfluoroalkyl Substance Exposure Based on a Nested Case–Control Study

Dan Cai, Shen-Pan Li, Yu-Ting Guo, Wei-Chun Chou, Zeeshan Mohammed, Rong-Liang Qiu, Guocheng Hu, Jianying Qi, Mingzhong Ren, Mingdeng Xiang, Zhenchi Li, Yang Zhou, Jinbo Huang, Minli Kong, Yanqi Xie, Cuilan Tang, Li-Zi Lin, Yunjiang Yu, Guang-Hui Dong, Xiao-Wen Zeng

Development of machine learning-based quantitative structure–activity relationship models for predicting plasma half-lives of drugs in six common food animal species

Pei-Yu Wu, Wei-Chun Chou, Xue Wu, Venkata N Kamineni, Yashas Kuchimanchi, Lisa A Tell, Fiona P Maunsell, Zhoumeng Lin

Toxicological Sciences, Volume 203, Issue 1, January 2025, Pages 52–66

2024

Impact of protein coronas on nanoparticle interactions with tissues and targeted delivery

Wei-Chun Chou, Zhoumeng Lin

​Current Opinion in Biotechnology 85, 103046

Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F–53B exposure

Shenpan Li, LuYin Wu, HuiXian Zeng, Jing Zhang, ShuangJian Qin, Li-Xia Liang, John Andersson, Wen-Jie Meng, Xing-Yu Chen, Qi-Zhen Wu, Li-Zi Lin, Wei-Chun Chou, Guang-Hui Dong, Xiao-Wen Zeng

Environmental Research 248, 118305

Development of a rapid aptamer-chemiluminescence sensor for detecting glyphosate pesticide residue in soybeans

Rui-Cian Weng, Min-Cheng Tsou, Jyun-Lin Lee, Chao-Ming Tseng, Yu-Fen Huang, Yu-Lin Xiao, Yen-Pei Lu, Wei-Chun Chou, Ruey-Feng Chang, Chun-Yu Chuang

Talanta 272, 125741

Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models

Kun Mi, Wei-Chun Chou, Qiran Chen, Long Yuan, Venkata N Kamineni, Yashas Kuchimanchi, Chunla He, Nancy A Monteiro-Riviere, Jim E Riviere, Zhoumeng Lin

​Journal of Controlled Release 374, 219-229

Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases: A population-based survey in the Pearl River Delta Region, China

Qi-Zhen Wu, Hui-Xian Zeng, John Andersson, Anna Oudin, Katja M Kanninen, Mu-Wu Xu, Shuang-Jian Qin, Qing-Guo Zeng, Bin Zhao, Mei Zheng, Nanxiang Jin, Wei-Chun Chou, Pasi Jalava, Guang-Hui Dong, Xiao-Wen Zeng

Journal of Hazardous Materials 470, 134161

Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans

Jing Zhang, Shen-Pan Li, Qing-Qing Li, Yun-Ting Zhang, Guang-Hui Dong, Alexa Canchola, Xiaowen Zeng, Wei-Chun Chou

​Environmental Science & Technology 58 (42), 18928-18939

Adverse outcome pathway for the neurotoxicity of Per-and polyfluoroalkyl substances: A systematic review

​Shenpan Li, Shuangjian Qin, Huixian Zeng, Weichun Chou, Anna Oudin, Katja M Kanninen, Pasi Jalava, Guanghui Dong, Xiaowen Zeng

​Eco-Environment & Health

Adverse outcome pathway for the neurotoxicity of Per-and polyfluoroalkyl substances: A systematic review

Z Lin, D Basili, WC Chou

Food and Chemical Toxicology 190, 114809

Preface to the special issue of Food and Chemical Toxicology on “New approach methodologies and machine learning in food safety and chemical risk assessment: Development of reproducible, open-source, and user-friendly tools for exposure, toxicokinetic, and toxicity assessments in the 21st century”

Zhoumeng Lin, Danilo Basili, Wei-Chun Chou

Food and Chemical Toxicology 190, 114809

LncRNA NR_030777 promotes mitophagy by targeting CDK1-related mitochondrial fission and ATG12 to attenuate paraquat-induced Parkinson's disease

Nengzhou Chen, Hong Hu, Jianping Tang, Fuli Zheng, Zhenkun Guo, Xinpei Lin, Michael Aschner, Wenya Shao, Guangxia Yu, Ping Cai, Wei-Chun Chou, Siying Wu, Huangyuan Li

​Environmental Pollution 349, 123875

Rebuttal to Correspondence on “Fetal Glucocorticoid Mediates the Association between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Neonatal Growth Index: Evidence from a Birth Cohort Study”

Dan Cai, Qing-qing Li, Zeeshan Mohammed, Wei-Chun Chou, Jinbo Huang, Minli Kong, Yanqi Xie, Yunjiang Yu, Guocheng Hu, Jianying Qi, Yang Zhou, Weihong Tan, Lizi Lin, Rongliang Qiu, Guanghui Dong, Xiao-Wen Zeng

Environmental Science & Technology 58 (43), 19568-19569

Physiologically based pharmacokinetic modeling of metal nanoparticles for risk assessment of inhalation exposures: a state-of-the-science expert panel review

CR Kirman, B Kent, J Bigelow, RA Canady, Q Chen, WC Chou, D Li, Z Lin, V Kumar, A Paini, P Poulin, LM Sweeney, SM Hays

Nanotoxicology 18 (6), 527-541

2023

Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling

Wei-Chun Chou, Zhoumeng Lin
Toxicological Sciences 191 (1), 1-14

An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice

Wei-Chun Chou, Qiran Chen, Long Yuan, Yi-Hsien Cheng, Chunla He, Nancy A Monteiro-Riviere, Jim E Riviere, Zhoumeng Lin
Journal of Controlled Release 361, 53-63

Meta-analysis of nanoparticle distribution in tumors and major organs in tumor-bearing mice

Qiran Chen, Long Yuan, Wei-Chun Chou, Yi-Hsien Cheng, Chunla He, Nancy A Monteiro-Riviere, Jim E Riviere, Zhoumeng Lin
ACS nano 17 (20), 19810-19831

Per-and polyfluoroalkyl substances in ambient fine particulate matter in the Pearl River Delta, China: Levels, distribution and health implications

Lu-Sheng Liu, Yu-Ting Guo, Qi-Zhen Wu, Mohammed Zeeshan, Shuang-Jian Qin, Hui-Xian Zeng, Li-Zi Lin, Wei-Chun Chou, Yun-Jiang Yu, Guang-Hui Dong, Xiao-Wen Zeng
Environmental Pollution 334, 122138

Food and Chemical Toxicology

Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per-and polyfluoroalkyl substances (PFAS).

Prenatal exposure to legacy and alternative per-and polyfluoroalkyl substances and neuropsychological development trajectories over the first 3 years of life

Qing-Qing Li, Jinbo Huang, Dan Cai, Wei-Chun Chou, Mohammed Zeeshan, Chu Chu, Yang Zhou, Lizi Lin, Hui-Min Ma, Cuilan Tang, Minli Kong, Yanqi Xie, Guang-Hui Dong, Xiao-Wen Zeng
Environmental Science & Technology 57 (9), 3746-3757

Fetal glucocorticoid mediates the association between prenatal per-and polyfluoroalkyl substance exposure and neonatal growth index: evidence from a birth cohort study

Dan Cai, Qing-qing Li, Zeeshan Mohammed, Wei-Chun Chou, Jinbo Huang, Minli Kong, Yanqi Xie, Yunjiang Yu, Guocheng Hu, Jianying Qi, Yang Zhou, Weihong Tan, Lizi Lin, Rongliang Qiu, Guanghui Dong, Xiao-Wen Zeng
Environmental science & technology 57 (31), 11420-11429

An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2. 5 exposure

Shuangjian Qin, Huixian Zeng, Qizhen Wu, Qingqing Li, Mohammed Zeeshan, Lizhu Ye, Yue Jiang, Rui Zhang, Xinhang Jiang, Miao Li, Rong Zhang, Wen Chen, Wei-Chun Chou, Guang-Hui Dong, Dao-Chuan Li, Xiao-Wen Zeng
 

Human biomonitoring reference values, exposure distribution, and characteristics of metals in the general population of Taiwan: Taiwan environmental survey for Toxicants (TESTs), 2013–2016

Kai-Wei Liao, Pau-Chung Chen, Wei-Chun Chou, Ivy Shiue, Hsin-I Huang, Wan-Ting Chang, Po-Chin Huang
International Journal of Hygiene and Environmental Health 252, 114195

Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per- and polyfluoroalkyl substances (PFAS)

Wei-Chun Chou, Lisa A Tell, Ronald E Baynes, Jennifer L Davis, Yi-Hsien Cheng, Fiona P Maunsell, Jim E Riviere, Zhoumeng Lin
Food and Chemical Toxicology 181, 114062

Unveiling the hidden dangers of plasticizers: A call for immediate action

PC Huang, WC Chou
Toxics 11 (6), 527

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